Genetic profiling of the 5-top cancers among Arabian populations in relation to their genealogical landscape: towards establishment of gene therapy platform in the region

Currently, there had been a worldwide growing interest in gene therapy, being the most sustainable therapeutic approach for cancers as well as genetic diseases for upcoming 50 years and beyond.1‒5 Furthermore, several researchers have reported that we can conduct a programmable editing of a target base in genomic DNA without double-stranded DNA cleavage5 and even further to this we can conduct a programmable base editing of A•T to G•C in genomic DNA without DNA cleavage.4 A particular example of the current application of CRISPR/Cas9 gene-editing technique is to eradicate HIV/AIDS.6 The genealogical culture and lifestyle of Arabs (about 400 million) is the driving force for the consanguineous marriage as favored and respected in all their communities with a range of 20‒60 %,7–9 which is higher than the isolated and rural communities particularly among the Bedouins. The prevailing rate of the congenital genetic diseases and disorder are being directed by the genealogical land escape all over the Arabs Countries. In fact, the vast majority of their internal marriages occur within the first-cousin relationship which highly provocate the prevalence of the autosomal recessive disorders in particular. The aim of this study is to determine the genealogical-cancers profiling among Arabian populations in order to establish a gene therapy platform as a new therapeutic approach in the region which will promote the overall managements of the familial cancer disease in the region.